Got a headache?

Ever think about how that wonderful aspirin is made?

Source: http://inventors.about.com/library/inventors/blaspirin.htmurce:

1899 Aspirin Bottle First Bottle of Aspirin More on Aspirin • Bayer Aspirin • 100 Years The History of Aspirin Since its market introduction under the trademark Aspirin in the year 1899, acetylsalicylic acid has attained a leading position world-wide in the prescription-free therapy of painful, inflammatory and feverish states. • Aspirin Foundation Developed by German chemist Felix Hoffmann in 1897 as a treatment for his father's arthritis, the basic ingredients of aspirin had long been known. Indeed, as long ago as the fifth century B.C •Aspirin - Molecule of the Month • Aspirin: A New Look at an Old Drug - Drug Use Warnings • Over-the-Counter Drugs and Headache: The Basics on Aspirin • Aspirin Sensitivity • Salicylic Acid • Salicylic Acid Chemical Structure • Salicylic Acid • A Miracle Drug Related Resources • Medical Innovations Hippocrates • Hippocrates:The Greek Miracle • Medicine History - Hippocrates • Hippocrates biography: his influence on the history of modern medicine • Hippocrates and Galen • Hippocrates and Hippocratic Oath Online By Mary Bellis Aspirin or acetylsalicylic acid, is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches. The drug works by inhibiting the production of prostaglandins, body chemicals that are necessary for blood clotting and which also sensitize nerve endings to pain. The father of modern medicine was Hippocrates, who lived sometime between 460 B.C and 377 B.C. Hippocrates was left historical records of pain relief treatments, including the use of powder made from the bark and leaves of the willow tree to help heal headaches, pains and fevers. By 1829, scientists discovered that it was the compound called salicin in willow plants which gave you the pain relief. According to "From A Miracle Drug" written by Sophie Jourdier for the Royal Society of Chemistry: "It was not long before the active ingredient in willow bark was isolated; in 1828, Johann Buchner, professor of pharmacy at the University of Munich, isolated a tiny amount of bitter tasting yellow, needle-like crystals, which he called salicin. Two Italians, Brugnatelli and Fontana, had in fact already obtained salicin in 1826, but in a highly impure form. By 1829, [French chemist] Henri Leroux had improved the extraction procedure to obtain about 30g from 1.5kg of bark. In 1838, Raffaele Piria [an Italian chemist] then working at the Sorbonne in Paris, split salicin into a sugar and an aromatic component (salicylaldehyde) and converted the latter, by hydrolysis and oxidation, to an acid of crystallised colourless needles, which he named salicylic acid." Henri Leroux had extracted salicin, in crystalline form for the first time, and Raffaele Piria succeeded in obtaining the salicylic acid in its pure state. The problem was that salicylic acid was tough on stomachs and a means of 'buffering' the compound was searched for. The first person to do so was a French chemist named Charles Frederic Gerhardt. In 1853, Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetylsalicylic acid. Gerhardt's product worked but he had no desire to market it and abandoned his discovery. In 1899, a German chemist named Felix Hoffmann, who worked for a German company called Bayer, rediscovered Gerhardt's formula. Felix Hoffmann made some of the formula and gave it to his father who was suffering from the pain of arthritis. With good results, Felix Hoffmann then convinced Bayer to market the new wonder drug. Aspirin was patented on February 27, 1900. The folks at Bayer came up with the name Aspirin, it comes from the 'A" in acetyl chloride, the "spir" in spiraea ulmaria (the plant they derived the salicylic acid from) and the 'in' was a then familiar name ending for medicines. Aspirin was first sold as a powder. In 1915, the first Aspirin tablets were made. Interestingly, Aspirin ® and Heroin ® were once trademarks belonging to Bayer. After Germany lost World War I, Bayer was forced to give up both trademarks as part of the Treaty of Versailles in 1919.